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Environmental fate & pathways

Biodegradation in water: screening tests

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Link to relevant study record(s)

Description of key information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.


According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.


For the assessment of the five (5) constituents (Ethyl 2,2,3,4-tetramethylpentanoate, Ethyl 2,2,3,3-tetramethylpentanoate, Pentanoic acid, 2,2,4,4-tetramethyl-, ethyl ester, Butanoic acid, 2,3-dimethyl-2-(1-methylethyl)-, ethyl ester and Butanoic acid, 2-ethyl-2,3,3-trimethyl-, ethyl ester) of the test item, (Q)SAR results were used for aerobic biodegradability in water. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.



Based on the results of BIOWIN v4.10 the test substance is predicted to be not readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
not biodegradable

Additional information

The biodegradation of the test substance was estimated by calculating the potential biodegradation of its five constituents using BIOWIN v4.10 contained in EPISuite v4.11. Based on the results, the test substance is predicted to be not readily biodegradable. The molecular weights and the number of fragments found in the constituents are within the range of the model