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EC number: -
CAS number: -
In the experiment, no precipitation of the
test substance was observed at any of the tested concentrations up to
In the experiment using the pre-incubation
method, the test item caused no cytotoxicity towards all bacteria
strains. The confirmation tests of the genotype did not show any
irregularities. The control of the titre was above the demanded value of
10E-9 bacteria/mL.The test item substance showed no increase in the
number of revertants in all bacteria strains in the experiment with the
pre- incubation method. No concentration-related increase over the
tested range was found.
A study was conducted to determine the
mutagenic potential of the test substance according to OECD Guideline
471, in compliance with GLP. The test substance was examined using four
strains of Salmonella typhimurium (TA1535, TA1537, TA98 and TA 100) and
Escherichia coli strain WP2uvrA in the Ames plate incorporation and
pre-incubation methods up to eight dose levels, in triplicate, both with
and without the addition of a rat liver homogenate metabolizing system
(10% liver S9 in standard co-factors). The dose range study was
performed in range of 15 to 5000 μg/plate. The test substance showed no
precipitates on the plates at any of the concentrations. The bacterial
background lawn was not reduced at any of the concentrations and no
relevant decrease in the number of revertants was observed in all
bacteria strains. The test substance showed no signs of toxicity towards
the bacteria strains in both the absence and presence of metabolic
activation. The results of this experiment showed that none of the
tested concentrations showed a significant increase in the number of
revertants in all tested strains, in the presence and the absence of
metabolic activation. Under the study conditions, the test substance was
not found to be mutagenic (Andres, 2019).
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