Registration Dossier
Registration Dossier
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EC number: 826-908-4 | CAS number: 1472631-98-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Materials and methods
- Principles of method if other than guideline:
- in vivo eye irritation study
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-[2-(methoxymethyl)-3-methylphenyl]-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-one
- EC Number:
- 826-908-4
- Cas Number:
- 1472631-98-3
- Molecular formula:
- C11 H14 N4 O2
- IUPAC Name:
- 1-[2-(methoxymethyl)-3-methylphenyl]-4-methyl-4,5-dihydro-1H-1,2,3,4-tetrazol-5-one
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- 72 hours (substance has not been removed by washing)
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
Results and discussion
In vivo
- Irritant / corrosive response data:
- In the observations made after application, iris congestion (score points: 1); and in respect of the conjunctiva, flushing (score points: 1), edema (score points: 1) and ocular discharge / secretion (score points: 1) were seen. These local reactions had all disappeared by 48 hours after applying the test substance. No local reactions were observed in the cornea throughout the observation period (Table 2).
Maximum value up to 72 hours after application: 11 (1 hour after application).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
