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Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31 March 2020 - 01 May 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31 March 2020 - 01 May 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Key result
Remarks on result:
other: Glass transition point: -76.7°C. No melting/freezing temperature between 25°C and -90°C.

TGA EXPERIMENT (PRELIMINARY TEST)

The weight of the sample decreased significantly at temperatures above 200°C: 25% decrease at 223°C and 70% decarease at 271°C.

Appearance of the sample after the experiment: yellow molten residue remained in the sample container (original colour: colourless).

The change of colour is an indicator for reaction and/or decomposition of the test item.

 

DSC EXPERIMENT 1

During cooling, a glass transition effect between -60°C and -90°C was found.

During heating a glass transition effect was observed between -90°C and -50°C. Between 100°C and 175°C an broad endothermic followed by a strong exothermic effect was observed starting at 200°C. The inflection point of the glass transition was -76.702°C. The endothermic effect was most likely obtained due to the evaporation of impurities of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item.

DSC EXPERIMENT 2

Experiment 2 was performed as a duplicate of Experiment 1, only the end temperature was 25°C instead of 223°C.

Similar results as in Experiment 1 were obtained. The inflection point of the glass transition was -76.732°C.

After the experiment, the residue remained in the sample container was unchanged.

DSC curve: see illustration below.

RESULT

The glass transition temperature: determined as the mean inflection point of Experiment 1 (-76.702°C) and Experiment 2 (-76.732°C).

Boiling temperature: the substance has no boiling temperature. Reaction and/or decomposition of the test item was observed during DSC experiments starting at 200°C (473K). Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started.

Conclusions:
A glass transition temperature of -76.7°C was determined. The substance has no melting/freezing temperature between 25°C and -90°C.

Executive summary:

The melting and boiling temperature of the test item were determined in a GLP study using Differential Scanning Calorimetry (DSC).

The experiments were in accordance with EC A.1, OECD 102 and OPPTS 830.7200 (melting temperature) and EC A.2, OECD TG 103 and OPPTS 830.722 (boiling temperature).

A glass transition effect was observed between -90°C and -50°C. Between 100°C and 175°C an broad endothermic, followed by a strong exothermic effect was observed starting at 200°C. The endothermic effect was most likely obtained due to the evaporation of impurities of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item.

The liquid substance has no melting/freezing temperature between 25°C and -90°C. From duplicate measurements the mean glass transition temperature was determined to be -76.7°C.

Boiling of the substance was not observed below the temperature at which reaction and/or decomposition started (i.e. at 200°C). It was concluded that the substance has no boiling temperature.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-aminoethylamino)ethanol
EC Number:
203-867-5
EC Name:
2-(2-aminoethylamino)ethanol
Cas Number:
111-41-1
Molecular formula:
C4H12N2O
IUPAC Name:
2-[(2-aminoethyl)amino]ethanol
Test material form:
liquid: viscous
Details on test material:
Physical Description: Colourless viscous liquid

Purity/Composition correction factor: No correction factor require

Storage Conditions: At room temperature protected from light container flushed with nitrogen

Test item handling: Use amber glassware or wrap container in aluminum foil

Results and discussion

Boiling point
Key result
Decomp. temp.:
°C
Remarks on result:
other: No boiling up to decomposition.

Any other information on results incl. tables

see IUCLID 4.2 melting point

Applicant's summary and conclusion

Conclusions:
Boiling of the substance was not observed below the temperature at which reaction and/or decomposition started (i.e. at 200°C).
Executive summary:

see IUCLID 4.2 melting point