Registration Dossier
Registration Dossier
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EC number: 952-811-2 | CAS number: 1792184-37-2
Endpoint summary
Administrative data
Description of key information
Skin sensitisation was conducted as per a weight of evidence based approach using DPRA, KeratinoSens and DEREK.
A DEREK assessment, a DPRA and a KeratinoSensTM assay were performed in accordance with Section 8.3 of Annex VII of Regulation (EC) No 1907/2006 as amended in Commission Regulation(EU)2016/1688 of 20 September 2016 and the strategy presented in ECHA Guidance on information requirements and chemical safety assessment Chapter R.7a. The DEREK assessment yielded no alerts on skin sensitization for the substance and predicted PF-06715298 to be a non-sensitizer. The DPRA was negative, as the substance did not show significant covalent binding with lysine and cysteine containing peptides. The DPRA classified PF-06715298 as 'no or minimal reactivity class'. PF-06715298 is classified as negative (no biologically relevant activation of the antioxidant/electrophile responsive element (ARE)-dependent pathway in keratinocytes) under the experimental conditions described in this report.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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