Registration Dossier

Toxicological information

Genetic toxicity: in vitro

Currently viewing:

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Title:
Sarah Nexus 3.1
Year:
2020
Bibliographic source:
Sarah for windows

Materials and methods

Principles of method if other than guideline:
- Software tool(s) used including version: Sarah Nexus 3.1
- Model(s) used: Sarah for Windows - Mutagenicity
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'Cross-reference'
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Test material form:
solid: particulate/powder

Results and discussion

Test results
Genotoxicity:
negative
Remarks on result:
other: prediction

Applicant's summary and conclusion

Conclusions:
The query structure is predicted to be negative with 52% confidence for the 'Mutagenicity in vitro' endpoint in the model: 'Sarah Model – 2020.1 '. The compound is in the domain of the model, and supporting hypotheses containing similar examples from the training set have been found.