Registration Dossier

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report Date:
2020

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: QSAR

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vitro

Results
Remarks on result:
positive indication of irritation
Remarks:
The result is from QSAR prediction.

Applicant's summary and conclusion

Interpretation of results:
Category 2B (mildly irritating to eyes) based on GHS criteria
Conclusions:
In summary, we applied the eye irritation prediction QSAR model in the molecular toxicity prediction software package ACD/TOX for predicting eye irritation of the compound 3,7,11,15-tetramethyl-2-hexadecen-1-ol. The QASR model predicted that the compound could have a moderate eye irritation. In addition, a compound having the skin irritation would have an eye irritation. Based on the model calculations in combination with literature-reported experimental eye irritation data of similar compounds, it was suggested that the compound 3,7,11,15-tetramethyl-2-hexadecen-1-ol would have a moderate eye irritation with a high possibility.