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EC number: 457-310-8 | CAS number: -
Mean 24 -72 hours
Table 1: Mean value eye irritation scores
In an OECD guideline study (TG 405), conducted according to GLP, approximately 93 mg of platinum (2 +) tetraammine (SP-4 -1) diacetate was instilled into one eye of each of three male New Zealand white rabbits. The other eye remained untreated and was used for control purposes.
Irritation of the conjunctivae, consisting of redness, chemosis and discharge (highest scores observed in an individual rabbit were 3, 2, 2 respectively) was observed in all three animals. The irritation had completely resolved within 14 days. No effects were seen on the iris or cornea. No corrosive effects were noted and there was no evidence of systemic toxicity. As the conjunctival redness score (calculated as mean of the scores at 24, 48 and 72 hr) was greater than or equal to 2 in all three animals, the test material met the criteria for classification as irritant category 2 according to EU CLP regulations.
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