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EC number: 457-310-8 | CAS number: -
In an OECD Test Guideline 404 study, to GLP, 0.5 g of platinum (2+) tetraammine (SP-4 -1) diacetate was applied to the clipped skin of 3 male New Zealand white rabbits. After 4 hours, the semi-occlusive dressings were removed and the skin sites assessed for signs of irritation (oedema and erythema/eschar) at 1, 24, 48 and 72 hours.
No erythema/eschar or oedema was seen at any of the observation points. The test material produced a primary irritation index of 0 and was classified as non-irritant to rabbit skin according to the Draize classification system. No corrosive effects were noted and there was no evidence of systemic toxicity. The test material did not meet the criteria for classification as irritant or corrosive according to EU CLP regulations.
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