Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to section 13 for the read-across justification.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
LOEC
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility

Description of key information

In the 48-h acute toxicity study of the read-across substance on Daphnia magna according to OECD T 202, no immobilisation observed in the control and in the 100 mg/L concentration group. In both groups no abnormal behaviour or appearance of test animals was noted. The 48-h NOEC was determined to be 100 mg/L. The 48-h LOEC and the EC50 values were determined to be > 100 mg/L (reference 6.1.3 -1).

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information

No study data with the test item is available for short-term toxicity to aquatic invertebrates. Therefore, a read-across to the read-across substance with a very similar chemical structure and comparable physico-chemical parameters is used to evaluate the potential for short-term toxicity to aquatic invertebrates of the test item.

 

The influence of the read-across substance on Daphnia magna was assessed in a 48-h Acute Immobilisation Test according to OECD TG 202. Young Daphnia were exposed to aqueous test media containing the read-across substance for 48 hours. Based on results obtained from a non-GLP preliminary experiment Daphnia were exposed to a single concentration of 100 mg/L (limit concentration). The test included a concurrent negative control. A static test was performed as the read-across substance was previously shown to be stable in the test medium for 48 hours. The analytically measured test item concentration remained within ± 20 % of the nominal during the test period of 48 hours; therefore, biological results are based on the nominal concentration. Healthy, young female daphnids with known origin, history and acclimatization conditions were used. The read-across substance concentration of 100 mg/L and the control (ISO Medium) were tested using 20 Daphnia (divided into 4 concurrent subgroups) each. The immobilisation of the test animals was recorded 24 and 48 hours after treatment. Environmental conditions were recorded. All measured values remained within acceptable ranges.

No immobilisation or any abnormal behaviour was observed in the control and the 100 mg/L concentration group after 48 hours of exposure. All validity criteria were within acceptable limits and therefore the study was considered valid.

The 48-h NOEC was determined to be 100 mg/L. The 48-h LOEC and the EC50 values were determined to be > 100 mg/L.