Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 900-021-3 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 Days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- EC Number:
- 900-021-3
- Molecular formula:
- 3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) :C20 H22O5, 3,5-Heptanedione-1,7 -bis(4-hydroxyphenyl) : C19H20O4, 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl) : C21H24O6
- IUPAC Name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Remarks:
- S. typhimurium TA 100
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- True negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Non Mutagenic
Applicant's summary and conclusion
- Conclusions:
- Bacterial Reverse Mutation Test in Salmonella typhimurium Tester strains for substance confirms it is non-mutagenic .
The study is performed in compliance with OECD guidelines No.471.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
