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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1978
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Groups of six mice were injected ip with increasing dose levels of the test compounds (geometric factor 1.2). Injection volumes were 0.01 ml/g body wt. LD50 values and 95 % confidence limits were calculated from cumulative mortality curves, at 24 and 144 hr.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-1,3-diol
EC Number:
207-997-3
EC Name:
Propane-1,3-diol
Cas Number:
504-63-2
Molecular formula:
C3H8O2
IUPAC Name:
propane-1,3-diol

Test animals

Species:
mouse
Strain:
ICR
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
"Injected ip with increasing dose levels of the test compound (geometric factor 1.2)"
No. of animals per sex per dose:
groups of six mice
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
5 236 mg/kg bw
95% CL:
>= 4 848 - <= 5 654
Remarks on result:
other: 24 h
Sex:
female
Dose descriptor:
LD50
Effect level:
4 779 mg/kg bw
95% CL:
>= 4 338 - <= 5 274
Remarks on result:
other: 144 h

Applicant's summary and conclusion

Conclusions:
The 24 h LD50 was found to be 4779 mg/kg bw.
Executive summary:

The test item was injected intraperitoneal with increasing dose levels to a group of six mice. The injection volume was 0.01 mL/g bw. The 24 h LD50 was found to be 68.8 mmol/kg bw and the 144 hr LD50 was found to be 62.8 mmol/kg bw. These values correspond to 5236 mg/kg bw and 4779 mg/kg bw, respectively.