Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2020-02-24 to 2020-02-28
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
808 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
3 000 mg/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
>= 5.77 - <= 5.89
Details on results:
According to the test guideline, the result found after a defined incubation time should not differ by more than 15 % from the result found after a shorter incubation time. After 48 hours in comparison to the 24 hours results, the measured concentration was stable compared to 24 hours incubation and slightly increased after 72 hours shaking (+3 %). The acceptance criterium was therefore fulfilled and the study is valid.

Table 1: Data of the Performance of the Water Solubility Test

Sample No.

1

2

3

4

5

6

Weighed amount of test item [mg]

147.27

153.04

160.31

160.60

151.87

151.63

Volume of water [mL]

50

50

50

50

50

50

Loading rate [mg/L]

2945

3061

3206

3212

3037

3033

Agitation time at 30°C [hours]

24

24

48

48

72

72

Equilibration time at 20°C [hours]

24

24

24

24

24

24

pH value of test item solution

5.89

5.84

5.79

5.87

5.77

5.83

The tabulated values of the samples represent rounded results obtained by calculation using the exact raw data.

Table 2: Results for Determination of Water Solubility

Shaking Time

Measured Concentration of Test Item in the Sample
x

Sample Preparation Factor

F

Concentration of Test Item Determined in

the Sample
c

Water Solubility

Mean Value

Overall Mean
± Std. Dev.

[Hours]

[mg/L]

 

[mg/L]

[mg/L]

[mg/L]

24

383

2.0

767

802

808
± 32

419

2.0

837

48

416

2.0

832

801

385

2.0

770

72

417

2.0

833

821

405

2.0

809

Conclusions:
The mean water solubility of the test item was determined to be 808 ± 32 mg/L (mean ± standard deviation) at 20 °C at pH values ranging from 5.77 to 5.89.
Executive summary:

A study was conducted according to OECD Test Guideline 105 (1995) using the Shake Flask method. After a shaking time of 24 hours, 48 hours and 72 hours, respectively, at 30 °C, the samples were equilibrated for another 24 hours at 20 °C. Afterwards, the samples were centrifuged, diluted and analyzed by HPLC with UV-detection. The water solubility of the test item was determined to be 808 ± 32 mg/L at 20 °C at pH values ranging from 5.77 to 5.89.

Description of key information

The mean water solubility of the test item was determined to be 808 ± 32 mg/L (mean ± standard deviation) at 20 °C at pH values ranging from 5.77 to 5.89.

Key value for chemical safety assessment

Water solubility:
808 mg/L
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD Test Guideline 105 (1995) using the Shake Flask method. After a shaking time of 24 hours, 48 hours and 72 hours, respectively, at 30 °C, the samples were equilibrated for another 24 hours at 20 °C. Afterwards, the samples were centrifuged, diluted and analyzed by HPLC with UV-detection. The water solubility of the test item was determined to be 808 ± 32 mg/L at 20 °C at pH values ranging from 5.77 to 5.89.