Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: authoritative database.
Title:
Acute inhalation toxicity
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity study of given test chemical in mouse.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
Cumene
EC Number:
202-704-5
EC Name:
Cumene
Cas Number:
98-82-8
IUPAC Name:
isopropylbenzene
Details on test material:
Name: Cumene
InChI: 1S/C9H12/c1-8(2)9-6-4-3-5-7-9/h3-8H,1-2H3
Smiles: Cc1(ccccc1)C(C)C
- Molecular formula : C9H12
- Molecular weight : 120.194 g/mol
- Substance type: organic

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Remarks on duration:
not specified
Concentrations:
10000 mg/m³
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for mortality and clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
10 000 mg/m³ air
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed
Clinical signs:
other: Observations were noted such as, changes in spleen, multiple effects in liver, kidney, ureter, and bladder, changes observed in both tubules and glomeruli.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute inhalation toxicity dose (LC50) was considered to be 10000 mg/m³, when mice were exposed to given test chemical via inhalation route for 7 hour exposure.
Executive summary:

The acute inhalation toxicity study was conducted by using test chemical in mice at the concentration of 10000 mg/m³. Animals were observed for mortality and clinical signs. 50% mortality was observed. Observations were noted such as, changes in spleen, multiple effects in liver, kidney, ureter, and bladder, changes observed in both tubules and glomeruli. Hence, LC50 value was considered to be 10000 mg/m³, when mice were exposed to given test chemical via inhalation route for 7 hour exposure.