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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
8.11.19 - 16.3.2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: CIPAC MT 181 CIPAC Handbook H (1998)
Version / remarks:
1998
GLP compliance:
yes (incl. certificate)
Key result
Medium:
other: p-xylene
Solubility:
< 10 g/L
Temp.:
20 °C
Key result
Medium:
other: dichloromethane
Solubility:
> 33 - < 40 g/L
Temp.:
20 °C
Key result
Medium:
methanol
Solubility:
> 40 - < 50 g/L
Temp.:
20 °C
Key result
Medium:
acetone
Solubility:
> 160 - < 200 g/L
Temp.:
20 °C
Key result
Medium:
ethyl acetate
Solubility:
> 67 - < 80 g/L
Temp.:
20 °C
Key result
Medium:
dimethylformamide
Solubility:
> 250 g/L
Temp.:
20 °C
Key result
Medium:
DMSO
Solubility:
> 250 g/L
Temp.:
20 °C
Test substance stable:
yes
Conclusions:
2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.
Executive summary:

The solubility of 2 -Amino-5 -chloro-N,3 -dimethylbenzamide in several organic solvents is determined according to CIPAC MT 181 by adding successive measured volumes of solvent to a known mass of the test item until complete dissolution is observed. Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide was determind as followed:

  • p-xylene lower than 10 g/L.
  • dichloromethane between 33 g/L and 40 g/L.
  • methanol between 40 g/L and 50 g/L.
  • acetone between 160 g/L and 200 g/L.
  • ethyl acetate between 67 g/L and 80 g/L
  • dimethylformamide higher than 250 g/L.
  • dimethylsulfoxide higher than 250 g/L.

as determien to

Description of key information

Solubility of 2 -amino-5 -chloro-N,3 -dimethylbenzamide in organic solvents was determined according to CIPAC 181 (1998).

2-Amino-5-chloro-N,3-dimethylbenzamide is good soluble in semi-polar solvents (DMF, DMSO) with a solubility of higher than 250 g/L. In aromatic (p-xylene) or halogenated solvents (dichloromethane) 2-amino-5-chloro-N,3-dimethylbenzamide only low solubility was found with 10 g/L or 33 - 40 g/L respectively.

Key value for chemical safety assessment

Additional information