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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

72 h ErC50 =  23.7 µg a.i./L (95% CL 23.2–24.5 µg a.i./L) / 72 h NOErC = 9.55 µg a.i./L;
Pseudokirchneriella subcapitata, OECD guideline 201, GLP

Key value for chemical safety assessment

EC50 for freshwater algae:
23.7 µg/L
EC10 or NOEC for freshwater algae:
9.55 µg/L

Additional information

In a growth inhibition test with Pseudokirchneriella subcapitata the effects of DOPA-Glycinate under static conditions for 72 hours (according to OECD guideline 201) were assessed.

Nominal concentrations: 2.5, 5.0, 10.0, 20.0 and 40.0 µg a.i./L

Measured concentrations: 1.1, 2.2, 4.57, 9.55 and 21.1 µg a.i./L

Due to the decrease of the test substance of more than 20% over the exposure period, the test results were based on mean measured concentrations (geometric mean).

The EC50 value for growth rate was only slightly higher than the highest test concentration of 21.1 µg a.i./L. It is therefore regarded feasible to use the extrapolated value as endpoint.

The NOEC values for growth rate, yield and biomass over 72 h were determined at 9.55 µg a.i./L (mean measured concentration).

NOErC = 9.55 µg a.i./L

ErC50 = 23.7 µg a.i./L (23.2–24.5 µg/L)

EbC50 = 19.5 µg a.i./L (19.4–19.5 µg/L)

EyC50=19.3 µg a.i./L (19.2–19.3 µg/L)