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Physical & Chemical properties

Water solubility

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Description of key information

>208 g/L (gravimetrical detemination after freeze-drying, non-guideline method; GLP)

Key value for chemical safety assessment

Water solubility:
208 g/L
at the temperature of:
20 °C

Additional information

DOPA-Glycinate (20% a.i.), constituting an aqueous solution of the pure active substance, was freeze-dried and the mass of the residue determined gravimetrically. The water solubility was determined to be > 20.83% (w/w), corresponding to > 208 g/L.

Although the available study was not conducted according to guideline EEC A.6, it is nevertheless established without reasonable doubt that the substance is soluble in water at concentrations of at least 200 g/L. Determination of a more accurate figure would be entirely immaterial for the risk assessment. Thus, the conduct of a water-solubility study following EEC A.6 would not provide a relevant contribution to the existing knowledge and is therefore considered to be scientifically unjustified.