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EC number: 401-450-4 | CAS number: 95154-01-1 (2-BENZOTHIAZOLYLTHIO)BERNSTEINSÄURE; BTTBS; HALOX 650; IRGACOR 252
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 16,1984 - May 30, 1984; Report June 12, 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- This test has been put under QA surveillance by the QAU
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (benzothiazol-2-ylthio)succinic acid
- EC Number:
- 401-450-4
- EC Name:
- (benzothiazol-2-ylthio)succinic acid
- Cas Number:
- 95154-01-1
- Molecular formula:
- C11H9NO4S2
- IUPAC Name:
- 2-(1,3-benzothiazol-2-ylsulfanyl)butanedioic acid
- Test material form:
- solid
- Details on test material:
- (benzothiazol-2-ylthio)succinic acid, Batch: 1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif:RAIf(SPF), F3-crosses of RII 1/Tif X RII 2/Tif
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Number of Animals Per Dose Level: 5 males and 5 females
Total Number of Animals: 10
Source:
CIBA-GEIGY LTD. Tierfarm, 4334 Sisseln, Switzerland
Initial Body Weight Range :
164-229 g
Initial Age:
7-8 weeks
Individual Identification:
by colour code using picric acid
Husbandry:
The animals were kept under conventional laboratory conditions. They were caged in groups of 5 in Macrolon cages type 4 with standardized soft wood bedding (Societe Parisienne des sciures, Pantin) . The animal room was air conditionned: temperature 22+3° C, relative humidity 55±15%, 12 hours light/day, approximately 15 air changes/h.
Diet:
Rat food, NAFAG No. 890, NAFAG AG, Gossau, SG (Switzerland), and water were provided ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Administration: oral, by gastric intubation (gavage)
Vehicle: Distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80
Dose Level: 5000 mg/kg bw.
Volume (ml/kg body weight) applied: 20
Administration of the Test Article: one single dose, per os
The animals were allocated to the different dose groups by random selection.
Prior to dosing, the animals were fasted overnight. - Doses:
- Dose Level: 5000 mg/kg bw.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
Mortality: daily; a.m. and p.m. on working uays, a.m. on weekend days
Signs and Symptoms: daily
Body weight: on days 1, 7, 14 and at death
Necropsies: Spontaneously dying animals were submitted to a gross necropsy as soon as possible; survivors at the end of the observation period. - Statistics:
- From the body weights, the group means and their standard deviations were calculated.
Where feasable, the LDSO including the 95% confidence limit were computed by the logit method (J. Berkson, J.Am. Stat. Ass. 39. 357-65, 1944)
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at a concentration of 5000 mg/kg bw.
- Clinical signs:
- other: Dyspnoea, exophthalmus, ruftled fur, and curved body position were seen. The surviving animals recovered within 10 days.
- Gross pathology:
- No gross lesions were found at necropsy.
Applicant's summary and conclusion
- Conclusions:
- The test item has practically no acute toxicity when administered orally to the albino rat. LD 50 > 5000 mg/kg/bw
- Executive summary:
In an acute toxicitystudy according to OECD Guideline No. 401, 5 male and 5 female albino rats were exposed to 5000 mg/kg/bw after oral administration.
Upon an acute oral administration and a 14 day post-treatment observation period, the following LD50 was determined for the test item.
LD50 in male rats; >5000 mg/kg bw.
LD50 in female rats; >5000 mg/kg bw
LD5O in rats of both sexes; > 5000 mg/kg bw
The test item has practically no acute toxicity when administered orally to the albino rat.
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