Naphtha (petroleum), catalytic reformed, co-processed with hydrocarbons derived from thermally cracked waste plastics

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented study report similar or equivalent to OECD 402. GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Gasoline

EC Number:

289-220-8

EC Name:

Gasoline

Cas Number:

86290-81-5

Constituent 2

Reference substance name:

unleaded gasoline

IUPAC Name:

unleaded gasoline

Test material form:

other: low viscosity liquid hydrocarbon

Details on test material:

(note: CAS No. not assigned in original reference).

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 hours

Doses:

3750 mg/kg

No. of animals per sex per dose:

4 males and 4 females/dose

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 3 750 mg/kg bw

Mortality:

One animal died on day 6 of the 14-day post-exposure observation period.

Clinical signs:

other: Erythema and edema were observed at the test site.

Gross pathology:

Necropsy revealed congested lungs and white areas on the liver. In addition, four animals were found to have congested lungs, but it was not clear that this effect was treatment-related.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The dermal LD50 for unleaded gasoline (API PS-6) in the rabbit is >3750 mg/kg. This finding does not warrant classification of the test material as an acute dermal toxicant under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).

Executive summary:

The acute toxicity of unleaded gasoline (API PS-6) was evaluated in rabbits via occlusive dermal application at 3750 mg/kg. Observations were made hourly for the first 4 hours immediately after dosing and twice daily (a.m. and p.m.) for the following 14 days. One animal died on day 6 post-exposure. Erythema and edema were observed at the test site during the observation period. Necropsy revealed congested lungs and white areas on the liver. In addition, four animals were found to have congested lungs, but it was not clear that this effect was treatment-related. The LD50 for unleaded gasoline (API PS-6) is >3750 mg/kg.

This finding does not warrant classification of the test material as an acute dermal toxicant under Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP).