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EC number: 701-349-8 | CAS number: -
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 July 2017 - 01 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- Regulation (EC) 440/2008 of 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Key result
- Melting / freezing pt.:
- >= 59.2 - <= 81 °C
- Decomposition:
- no
- Sublimation:
- no
- Remarks on result:
- other: Mean value
- Conclusions:
- The test item has a mean melting point of 59.2 - 81.0 °C ± 0.5 °C (332.35 - 354.15 K ± 0.5 K).
- Executive summary:
EU Method A.1. – The melting point/freezing point of the test item was determined using the Differential Scanning Calorimeter (DSC) method. The procedure employed was designed to be compatible with Method A.1. Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Aliquots of test item (0.0053 – 0.0058 mm) were placed in a crucible and subjected to heating at a rate of 1 °C/min from 25 to 110 °C. Heating was continued until melting of the sample was observed. The main test was performed two times.
The mean melting temperature of the test item was determined to be 59.2 - 81.0 °C ± 0.5 °C.
Reference
Evaluation of Data:
The melting/freezing point is defined as the point at which phase transition from solid to liquid state (or vice versa) at normal atmospheric pressure takes place. As the phase transition of many substances takes place over a large temperature range, it is often described as a melting/freezing range. During thermal analysis, the peak width of an endothermic reaction also depends on sample amount and heating rate. Therefore, the onset point of the relevant endothermic peak is usually stated as the freezing/melting point. If the endothermic peak/s is poorly defined, a range may be stated. Measured temperatures were converted from °C to K using Equation 1.
Equation 1:
T = t + 273.15
where:
T = Thermodynamic temperature, Kelvin (K)
t = Celsius temperature, degrees Celsius (°C)
Results:
Table 2: Thermographic Data – Preliminary Screen
Thermal Event |
Interpretation |
Temperature |
|||
Preliminary Test, Screen 1 |
Preliminary Test, Screen 2 |
||||
°C |
K |
°C |
K |
||
Endotherm (onset) |
Start of melting |
67.2 |
340.2 |
66.6 |
339.8 |
The residue in the crucibles from the preliminary tests was observed to be dark brown staining around the periphery of the crucible most likely due to decomposition.
Table 3: Thermographic Data – Preliminary Screen
Thermal Event |
Interpretation |
Temperature |
|||
Main Test, Determination 1 |
Main Test, Determination 2 |
||||
°C |
K |
°C |
K |
||
Endotherm (lower limit) |
Start of melting |
59.6 |
332.8 |
58.9 |
332.1 |
Endotherm (upper limit) |
End of melting |
80.9 |
354.1 |
81.0 |
354.2 |
Conclusion:
The melting point of the test item has been determined to be in the range of 59.2 to 81.0 °C (332.8 to 354.0 K).
Description of key information
Melting Point: 59.2 - 81.0 °C ± 0.5 °C (332.35 - 354.15 K ± 0.5 K); EU Method A.1.; R. Butler (2018)
Key value for chemical safety assessment
Additional information
EU Method A.1. – The melting point/freezing point of the test item was determined using the Differential Scanning Calorimeter (DSC) method. The procedure employed was designed to be compatible with Method A.1. Melting/Freezing Temperature of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Aliquots of test item (0.0053 – 0.0058 mm) were placed in a crucible and subjected to heating at a rate of 1 °C/min from 25 to 110 °C. Heating was continued until melting of the sample was observed. The main test was performed two times.
The mean melting temperature of the test item was determined to be 59.2 - 81.0 °C ± 0.5 °C.
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