Registration Dossier
Registration Dossier
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EC number: 701-341-4 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The NOAEL for reproductive and developmental effects from the multigenerational study of TPP, a close analog of DPDP, is 40 mg/kg bw/day (the top dose). The overall NOAEL from this study was 15 mg/kg bw/day due to systemic effects not related to reproductive or developmental endpoints.
Short description of key information:
There is no evidence of reproductive performance or developmental effects from TPP, analog to DPDP.
Justification for selection of Effect on fertility via oral route:
There is a reliable reproductive and developmental effects study of TPP, a close analog to DPDP.
Effects on developmental toxicity
Description of key information
There were no developmental or reproductive effects in a reliable study of TPP, a close chemical analog to DPDP.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
The NOAEL for reproductive and developmental effects from the multigenerational study of TPP, a close chemical analog of DPDP, is 40 mg/kg bw/day (the top dose). The overall NOAEL from this study was 15 mg/kg bw/day due to systemic effects not related to reproductive or developmental endpoints.
Justification for selection of Effect on developmental toxicity: via oral route:
There is a reliable reproductive and developmental effects study of TPP, a close analog to DPDP.
Justification for classification or non-classification
No specific effects on toxicity related to the reproductive or developmental endpoints, as such DPDP is not classified as a reproductive hazard.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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