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Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
40 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Additional information

The NOAEL for reproductive and developmental effects from the multigenerational study of TPP, a close analog of DPDP, is 40 mg/kg bw/day (the top dose). The overall NOAEL from this study was 15 mg/kg bw/day due to systemic effects not related to reproductive or developmental endpoints.


Short description of key information:
There is no evidence of reproductive performance or developmental effects from TPP, analog to DPDP.

Justification for selection of Effect on fertility via oral route:
There is a reliable reproductive and developmental effects study of TPP, a close analog to DPDP.

Effects on developmental toxicity

Description of key information
There were no developmental or reproductive effects in a reliable study of TPP, a close chemical analog to DPDP.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
40 mg/kg bw/day
Study duration:
subchronic
Species:
rat
Additional information

The NOAEL for reproductive and developmental effects from the multigenerational study of TPP, a close chemical analog of DPDP, is 40 mg/kg bw/day (the top dose). The overall NOAEL from this study was 15 mg/kg bw/day due to systemic effects not related to reproductive or developmental endpoints.


Justification for selection of Effect on developmental toxicity: via oral route:
There is a reliable reproductive and developmental effects study of TPP, a close analog to DPDP.

Justification for classification or non-classification

No specific effects on toxicity related to the reproductive or developmental endpoints, as such DPDP is not classified as a reproductive hazard.

Additional information

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