Registration Dossier
Registration Dossier
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EC number: 701-341-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on both the results of a guinea pig maximization test (GPMT) in DPDP and read-across data from analog substances (triphenyl phosphite (TPP) and diisodecyl phenyl phosphite (DDPP)), DPDP is expected to be a skin sensitiser. It's not clear that DPDP would be as strongly sensitising as TPP given the less than conclusive results from the GPMT and the fact that DDPP had an EC3 concentration of 40% in a recent LLNA study.
Migrated from Short description of key information:
There is a guinea pig maximisation study of DPDP that showed positive responses in 6 to 9 of the 10 test animals over a series of challenges. The study authors noted that the responses were atypical and could be a sign of irritation rather than sensitisation. They concluded that the results were ambiguous. However, based on recent LLNA studies from analog phosphite substances (triphenyl phosphite, diisodecyl phenyl phosphite, and triisodecyl phosphite) , DPDP is expected to be a skin sensitiser.
Justification for classification or non-classification
DPDP showed positive responses in a guinea pig maximisation study and analogs were positive in LLNA studies. DPDP is classified as a skin sensitiser.
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