Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-341-4 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study using standard protocols.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phosphorous acid, diphenyl isodecyl ester
- Molecular formula:
- C22H31O3P
- IUPAC Name:
- Phosphorous acid, diphenyl isodecyl ester
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Reference substance name:
- Diisodecyl phenyl phosphite
- EC Number:
- 247-098-3
- EC Name:
- Diisodecyl phenyl phosphite
- Cas Number:
- 25550-98-5
- Molecular formula:
- C26H47O3P
- IUPAC Name:
- Reaction products of triphenyl phosphite and isodecanol (1:2)
- Reference substance name:
- Grouped, low level constituents (1) - see description
- Molecular formula:
- C21H29O3P and C23H33O3P
- IUPAC Name:
- Grouped, low level constituents (1) - see description
- Reference substance name:
- Grouped, low level constituents (2) - see description
- Molecular formula:
- N/A
- IUPAC Name:
- Grouped, low level constituents (2) - see description
- Reference substance name:
- Triisodecyl phosphite
- EC Number:
- 246-998-3
- EC Name:
- Triisodecyl phosphite
- Cas Number:
- 25448-25-3
- Molecular formula:
- C30H63O3P
- IUPAC Name:
- Phosphorus acid, triisodecyl ester
- Reference substance name:
- Grouped, low level constituents (3) - see description
- Molecular formula:
- N/A
- IUPAC Name:
- Grouped, low level constituents (3) - see description
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: right eye served as control for each rabbit
- Amount / concentration applied:
- 0.1 gram applied in left eye of each rabbit
- Duration of treatment / exposure:
- 4 days
- Observation period (in vivo):
- 4 days
- Number of animals or in vitro replicates:
- 6 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1-4 days
- Remarks on result:
- other: no responses
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1-4 days
- Remarks on result:
- other: no responses
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1-4 days
- Remarks on result:
- other: Slight redness in test eye
- Irritant / corrosive response data:
- Slight redness in the eyes of most rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Only slight redness was observed in test eyes, no iris or corneal effects.
- Executive summary:
Slightly irritating to eyes, no significant effects on the iris or cornea. DPDP is not classified as an eye irritant based on these results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
