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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
flash point of flammable liquids
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because the flash point is only relevant to liquids and low melting point solids
Cross-reference
Reason / purpose for cross-reference:
data waiving: supporting information
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 September - 30 October 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
EC No. 440/2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Batch No.: 1000146/01
Storage Conditions: Freezer (approx. -15 °C)
Key result
Melting / freezing pt.:
123.14 °C
Atm. press.:
>= 1 007.9 - <= 1 010.5 hPa
Decomposition:
yes
Decomp. temp.:
ca. 130 °C

During the heating phase a distinct endothermic effect was observed in the temperature range of 110 – 130 °C, which can be assigned to the melting of the test item. This endothermic effect is directly followed by an exothermic effect in the temperature range of 130 – 160 °C with an average decomposition energy of -80 J/g. A second exothermic effect could be observed in the temperature range 160 – 220 °C with an average decomposition energy of -70 J/g. This exothermic effect is directly followed by an endothermic effect. A third brought endothermic effect could be observed in the temperature range of 280 – 390 °C.

Results of the DSC-measurement

No.  Sample weight (mg)  Onset of effect (°C)  Range of effect (°C)  Weight loss (mg)  Atmospheric pressure (hPa)

PN18331

 7.30

 123.16

110 -130 (endo)

130 -160 (exo)

160 -220 (exo)

220 -230 (endo)

280 -390 (endo)

5.45 

 1010.5

PN18382

 7.13

 123.11

110 -130 (endo)

130 -160 (exo)

160 -220 (exo)

220 -240 (endo)

270 -390 (endo)

 5.31

 1007.9

As the onset temperatures of the first endothermic effect in both tests deviate by less than 0.5 K from their mean value of 123.14 °C, this temperature can be used as melting point. The test item has a melting point of 123.14 °C accompanied by its decomposition.

Conclusions:
The test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) has a melting point of 123.14 °C at atmospheric pressure (1007.9 – 1010.5 hPa) accompanied by its decomposition starting at a temperature of approx. 130 °C as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
Executive summary:

The test item Nicotinamide-beta-D-riboside bromide (CAS no. 78687-39-5) has a melting point of 123.14 °C at atmospheric pressure (1007.9 – 1010.5 hPa) accompanied by its decomposition starting at a temperature of approx. 130 °C as determined by differential scanning calorimetry according to Regulation EC No. 440/2008 Method A.1. and OECD Test Guideline 102 (1995).

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion