Registration Dossier

Administrative data

First-aid measures

4.1 Description of first aid measures
General advice
In the case of accident or if you feel unwell, seek medical advice immediately (show the safety data sheet to the doctor in attendance).
IF INHALED
Move to fresh air. Artificial respiration and/or oxygen may be necessary. Cosult a doctor after significant exposure.
In case of skin contact
Wash off with soap and plenty of water. Take off contaminated clothing and shoes immediately.If skin irritation persists, call a doctor.
In case of eye contact

Fire-fighting measures

5.1 Extinguishing media:
Suitable extinguishing media: Water, carbon dioxide, dry powder, foam.

5.2 Special hazards arising from the substance or mixture:
Stable at normal temperatures

5.3Advice for firefighters:
Special protective equipment: Use self-contained breathing apparatus. Wear full protective suit.
Further information: Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Avoid discharging extinguishing water in the environment.

Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures:
Particle full face respirator or powered air purifying respirator. Suitable gloves. Dedicated work clothes.

6.2 Environmental precautions:
Avoid any spreading of the product. Prevent entry into drains and/or watercourses.

6.3 Methods and materials for containment and cleaning up:
General advice: Sweep and shovel the solid product into a container specially adapted for its recovery or destroying (avoiding dust formation). Close and label thoroughly.
Cleaning of contaminated zone: After cleaning up the product, rinse the polluted area with water.

6.4 Reference to other sections:

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for onsite isolated intermediates and, in case the substance is transported for the place of manufacture, then handled and used at the Cramlington site under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at the site. A summary of the controls is include in IUCLID Section 13. The substance is transformed into a final Active Pharmaceutical Ingredient which is exempt from REACH.

Precautions for safe handling:
Advice on safe handling (industrial scale): Local ventilation and emission point dust extraction. Enclosed transfer recommended. Take precautionary measures against electrostatic loading. Earth vessels and equipment well.
Advice on safe handling (laboratory scale): Handling in a hood.

Conditions for safe storage, including any incompatibilities:
Requirements for storage rooms and vessels: Keep containers tightly closed in a cool, well-ventilated place. Keep in a dry place.
Advice on common storage: Do not store with strong oxidizing agents, strong acids or bases. Store away from heat and sources of ignition.
Further information on storage conditions: Keep in a well closed container, away from moisture and light.
Storage temperature: Keep at room temperature (between 15 - 30°C).
Sensitivity: No particular observation.

Transport information

Land transport (ADR/RID)

UN number:
Not regulated. Not Dangerous Goods
Shippingopen allclose all
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
Not regulated. Not Dangerous Goods
Shippingopen allclose all
Remarksopen allclose all

Marine transport (IMDG)

UN number:
Not regulated. Not Dangerous Goods
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
Not regulated. Not Dangerous Goods
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported for the place of manufacture, then handled and used at the Cramlington site under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at the site. A summary of the controls is include in IUCLID Section 13. The substance is transformed into a final Active Pharmaceutical Ingredient which is exempt from REACH.

Occupational Exposure Limits:
OEL-8h (J&J PBOEL-HHC):1mg/m3

Engineering measures: Contained system. Local extraction when sampling
Personal protection equipment
Respiratory protection: Particle full face mask or powered-air purifying respirator (EN 141). ABEK
Hand protection: Suitable gloves.
Eye/face protection: See respiratory protection.
Body Protection: Dedicated working clothes recommended.
Hygiene measures: Wash hands

Stability and reactivity

Safety remarks: Dust may be explosive (no data available).

Reactivity: No data available.
Chemical stability: No data available.
Possibility of hazardous reactions: Oxidizing agents, acids
Conditions to avoid: Heat and source of ignition.
Incompatible materials: Strong oxidizing agents.
Hazardous decomposition products: Hydrogen fluoride, oxides of carbon

Disposal considerations

Dispose in accordance with current regulations and, if necessary, after consultation with the site operator and/or with the responsible authority.
Product: Can be incinerated, when in compliance with local regulations.