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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
26-08-2019 to 25-10-2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP ; All relevant validity criteria were met.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
25.9 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
6.1
Remarks on result:
other: Average of concentrations reported for all vessels between 24-72h.
Water solubility:
26 g/L
Conc. based on:
test mat.
Incubation duration:
24 h
Temp.:
20 °C
pH:
6.1
Remarks on result:
other: Concentration in water at 24h.
Water solubility:
25.9 g/L
Conc. based on:
test mat.
Incubation duration:
48 h
Temp.:
20 °C
pH:
6.1
Remarks on result:
other: Concentration in water at 48h.
Water solubility:
25.7 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
6.1
Remarks on result:
other: Concentration in water at 72h.

The preliminary estimate of the water solubility at room temperature was 25.9 g/L. The solution had a pH of 6.1.

The main test results are as follows:

 Stirring time [hours] Analysed concentration [g/L]  pH 
 24  26.0  6.1
 48  25.9  6.1
 72  25.7  6.1
 Mean average (24 -72h)  25.9  6.1

For all solutions, the measured pH was 6.1. No test item was detected in the pretreated sample from the blank water mixture. No pH measurement was performed on the blank water mixture.

The average water solubility observed over the readings taken between 24 and 72h was found to be 25.9 mg/L.

Conclusions:
Interpretation of results: sparingly soluble (10-33 g/L)
The substance water solubility was determined to be 25.9 g/L of solution at 20.0 °C and pH 6.1.
Executive summary:

The water solubility of the test item was determined using the flask method according to EU Method A.6, OECD Method 105 and EPA OPPTS 830.7840 under GLP. In the definitive test, mixtures of test item and double-distilled water were added to three separate vessels. The mass of test item was measured, and a volume of water was added. The flasks were equilibrated at 20°C with agitation. The solutions were centrifuged and then analysed via UPLC. The pH of each solution was also measured. The water solubility of the test item was determined to be 25.9 g/L of solution at 20.0 °C and pH 6.1.

Description of key information

Water Solubility: 25.9 g/L at 20 °C and pH 6.1, EU Method A.6, OECD 105 and EPA OPPTS 830.7840 – flask method, 2019

Key value for chemical safety assessment

Water solubility:
25.9 g/L
at the temperature of:
20 °C

Additional information

Key study : EU Method A.6 / OECD TG 105 / EPA OPPTS 830.7840 - The water solubility of the test item was determined using the flask method according to EU Method A.6, OECD Method 105 and EPA OPPTS 830.7840 under GLP. In the definitive test, mixtures of test item and double-distilled water were added to three separate vessels. The mass of test item was measured, and a volume of water was added. The flasks were equilibrated at 20°C with agitation. The solutions were centrifuged and then analysed via UPLC. The pH of each solution was also measured. The water solubility of the test item was determined to be 25.9 g/L of solution at 20.0 °C and pH 6.1.