Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed according to OECD and GLP guidelines
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report Date:
1991

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Fu-Albino outbred stock Ibm:RORO
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
arachis oil
Doses:
0 and 2000 mg/kg
No. of animals per sex per dose:
5 per sex per dose
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD 50 is > 2000 mg/kg bw
Executive summary:

Assessed with this method Propenylmethylether has a very low order of toxicity (approx. LD50 p.o. rat > 2000mg/kg body weight). All animals showed control behaviour during the whole 14-day observation period. All animals showed weight gain within normal limits. No signs of gross pathological changes were found by necropsy at the end of the observation period.