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Reaction products of 4-Diazo-3,4-dihydro-7-nitro-3-oxo-1-naphthalenesulfonic acid coupled with 7-Amino-4-hydroxy-2-naphthalenesulfonic acid, subsequently chelated with Chromium(3+) and cobalt(3+), further mixed with reaction products of 2,4,6-Trichloro-1,3,5-triazine and Ethanol, 2-[(4-aminophenyl)sulfonyl]-, 1-(hydrogen sulfate), sodium salts
EC number: 948-044-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
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- Auto flammability
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- Oxidation reduction potential
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- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Gene mutation study in bacteria
Everzol SR98 have two components, metal complex 1 and metal complex 2. Both metal complexes may be dissociated into coordination compound 3 and metal ions Cr3+ and Co 3+ under the effect of gastric acid. We applied two Ames Test prediction softwares, ACD/Tox Ames Test prediction model and DS/TOPKAT Ames Test QSAR model, to predict a positive Ames Test result for the compound 3 in a very low possibility. On the other hand, eitherCr3+ or Co2+exhibited genotoxicity according to literature-reported data. Furthermore, Co3+ may be transferred into Co2+ in vivo. Therefore, it would be rational to predict both metal complexrs 1 and 2 in Everzol SR98 would have genotoxicity, a positive result in Ames Test in a high possibility.
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- January 9, 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
ACD/TOX and DS/TOPKAT
2. MODEL
ACD/Tox Ames Test module and QSTR model of DS/TOPKAT - Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Genotoxicity:
- positive
- Remarks on result:
- mutagenic potential (based on QSAR/QSPR prediction)
- Conclusions:
- It would be rational to predict both metal complexes 1 and 2 in Everzol SR98 would have genotoxicity, a positive result in Ames Test in a high possibility.
- Executive summary:
In this report, we take advantage of ACD/TOX Ames Test result prediction module and DS/TOPKAT Ames Test result QSTR model, respectively, to predict the genotoxicity (Ames Test) of two metal complex components 1 and 2 of Everzol SR98 in combination with corresponding literatures. Althought the coordination agent 3 in both metal complexes was predicted to have a positive Ames Test result in a very low possibility by both ACD/Tox Ames Test and DS/TOPKAT Ames test QSTR models, the literature data indicated that both Cr3+ and Co3+ may have genotoxicity. Therefore, both components 1 and 2 in Everzol SR98 would have a positive result in Ames Test with a high possibility.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Additional information
Justification for classification or non-classification
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