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EC number: 948-044-8 | CAS number: -
Table 1. Initial and Final Weights of the Animals and Grading of Ocular Reactions Observed during the Test.
+: Presence; -: Ausence; NR: Not realized
Table 2. Clinical Signs
Clinical Signs / Period of Evaluation
0: None visual alterations observed.
This test using the procedures outlined in the BIOAGRI Study Plan for 16264.465.102.17. All the animals presented body weight gain during the observation period. The test was initially conducted using one New Zealand White rabbit. Because no severe ocular reaction was observed in the initial test, two additional New Zealand White rabbits were tested to confirm the response. Each animal received a 0.1 g dose of pure test item in the conjunctival sac of the right eye. After application the animals were examined the ocular reaction, behavioral and clinical alterations at approximately 1, 24, 48 and 72 hours. The untreated left eye was used as a negative control. The Everzol SR98 applied in tested eye of all rabbits caused hyperemia and chemosis and do not have retention of fluorescein sodium dye on the surface of the cornea. After the evaluation of 48 hours, there was regression of eyes reactions in tested eyes of all rabbits. After the evaluation of 72 hours, finalizing the study and all rabbits do not note any behavioral or clinical change related to treatment during the observation period.
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