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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 15 October, 2019 to 23 October, 2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Type of method:
flask method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
<= -4.15
Temp.:
25 °C
pH:
6
Type:
Pow
Partition coefficient:
<= 0
Temp.:
25 °C
pH:
6

Table 1. Results of the main study - n-octanol solubility of Everzol SR98

Stirring time

(hours)

Cn-octanol

(g/l)

Mean

(g/l)

MD%

pH

Temperature

(°C)

24

3.05×10-2

3.18×10-2

8.7

6.0

25.0 ± 0.5

48

3.16×10-2

72

3.32×10-2

Table 2. Summary

Sample Name

Cn-octanol(g/l)

Cwater(g/l)*

Pow= Cn-octanol/ Cwater

log Pow

Everzol SR98

3.18×10-2

444

≤ 7.16×10-5

≤ -4.15

*The data from EVERLIGHT Project 191014-01

Conclusions:
According to OECD 107 and EU Method A.8, the log Pow of Everzol SR98 was ≤ -4.15.
Executive summary:

This test using the procedures outlined in the EVERLIGHT Study Plan for 191009-14, OECD 107 and EU Method A.8. The water solubility of Everzol SR98 was 444 g/l and a solubility of Everzol SR98 in octanol was 3.18×10-2g/l. The Pow, calculated as the quotient of the octanol and water solubility, is 7.16 × 10-5. Therefore, the log Pow of Everzol SR98 was -4.15.

Description of key information

The log Pow of Everzol SR98 was < -4.15 (OECD TG107 and EU Method A.8).

Key value for chemical safety assessment

Log Kow (Log Pow):
-4.15

Additional information

The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test sample was < 15%. The water solubility of Everzol SR98 was 444 g/l and a solubility of Everzol SR98 in octanol was 3.18×10-2g/l. The Pow, calculated as the quotient of the octanol and water solubility, is 7.16 × 10-5. Therefore, the log Pow of Everzol SR98 was -4.15.