Registration Dossier

Diss Factsheets

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: MI16A047
Dissociating properties:
yes
No.:
#1
pKa:
2.6
Temp.:
20 °C

 

 Salt concentration of solution (g/l)  Molarity of solution (g/mol)

 Molar conductivity (µS/cm/mole)

 Degree of dissociation (α)

Dissociation constant

Solution 4

4.9660

0.0111

13784

0.32

0.0017

Solution 5

2.5380

0.0057

21228

0.49

0.0027

Solution 6

1.2690

0.0028

28464

0.66 

0.0036

Solution 7

0.6345

0.0014 

32786 

0.76 

0.0034

Solution 8

0.3173 

0.0007

37143

0.86 

0.0038

Solution 9

0.1586

0.0004

35750

0.83

0.0016

Solution 10 

0.0793 

0.0002

38500 

0.89 

0.0015 

Solution 11 

0.0397 

0.0001 

41000 

0.95 

0.0019 

#

#

Average dissociaiton constant = 0.0025

Standard deviation of dissociation constant = 0.0010

pKc = 2.60

Conclusions:
The dissociaiton constant is 2.60.
Executive summary:

In an OECD guideline study (OECD 112), the dissociation of Marlon AMI 80 has been investigated. The dissociation constant is found to be 2.40.

Description of key information

In a OECD guideline study (OECD 112) the dissociation constant has been measured. The pKc is 2.6.

Key value for chemical safety assessment

pKa at 20°C:
2.6

Additional information