Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
EC Number:
609-858-6
Cas Number:
406-78-0
Molecular formula:
C4H3F7O
IUPAC Name:
1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether
Test material form:
liquid

Study design

Analytical monitoring:
yes
Buffers:
BUffers were used of pH 4, pH 7 and pH 9

Results and discussion

Preliminary study:
In the blank buffer solution a small peak at the test substance position was detected. The contribution of this peak to the samples taken at t=120 hours was less than 0.07% and was therefore considered negligible.

At pH 4, pH 7 and pH 9, a decrease in concentration> 10% was observed after 5 days. This was probably due to the volatility of the test substance, i.e. partial evaporation into a very small volume of headspace. Therefore additional samples were taken after 14 days of incubation. The decrease in concentration between 5 and 14 days of incubation was < 10%. Therefore it was concluded that the half-life time at 25'C is > 1 year.
Transformation products:
no
Dissipation DT50 of parent compound
Key result
Remarks on result:
hydrolytically stable based on preliminary test

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Based upon the conditions of the test, the preliminary study demonstrated that the test compound is hydrolytically stable.