Registration Dossier
Registration Dossier
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EC number: 201-325-2 | CAS number: 81-11-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- other: secondary source
- Title:
- SIDS INITIAL ASSESSMENT REPORT
- Author:
- OECD SIDS
- Year:
- 1 996
- Bibliographic source:
- SIDS INITIAL ASSESSMENT REPORT
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study for the given test chemical.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- EC Number:
- 201-325-2
- EC Name:
- 4,4'-diaminostilbene-2,2'-disulphonic acid
- Cas Number:
- 81-11-8
- Molecular formula:
- C14H14N2O6S2
- IUPAC Name:
- 2,2'-ethene-1,2-diylbis(5-aminobenzenesulfonic acid)
- Test material form:
- solid
- Details on test material:
- - IUPAC Name: 4,4'-diaminostilbene-2,2'-disulphonic acid
- Mol. formula: C14H14N2O6S2
- Molecular Weight: 370.405 g/mole
- InChI: InChI=1S/C14H14N2O6S2/c15-11-5-3-9(13(7-11)23(17,18)19)1-2-10-4-6-12(16)8-14(10)24(20,21)22/h1-8H,15-16H2, (H,17,18,19)(H,20,21,22)/b2-1+
- Smiles: Nc1ccc(\C=C\c2ccc(N)cc2S(=O)(=O)O)c(c1)S(=O)(=O)O
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No symptoms
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg bw, when Wistar male rats were treated with the given test chemical via oral route.
- Executive summary:
The acute oral toxicity study was conducted by using the given test chemical in Male Wistar rats at the concentration of 5000 mg/kg bw. Animals were observed for mortality and signs of toxicity. No mortality and clinical symptoms were observed. Hence, the LD50 value was considered to be >5000 mg/kg bw, when Wistar male rats were treated with the given test chemical via oral route.
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