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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19.-25.06.2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
column elution method
Key result
Water solubility:
< 0.04 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: pH not indicated

Preliminary Visual Estimation of the Water Solubility

 

The solubility of the test item in water was found to be below 8.6 mg/L (without correction for the purity). According to the guideline the column elution method is the appropriate method for solubilities below 10 mg/L therefore this method was used for the main test.

Appearance of the test mixtures

Amount of the test item in mg

Total volume in mL

Appearance of mixture

17.1

100

undissolved

12.0

500

undissolved

4.3

500

undissolved

 

Concentration and pH

 

Column 1

Fraction
no.

V
in mL

PH

water solubility
in µg/L

21

18.0

5.6

< 44

22

18.0

5.7

< 44

23

18.0

5.7

< 44

24

18.0

5.7

< 44

25

18.0

5.7

< 44

The water solubility was found to be below the quantification limit of 44 μg/L.

 

Column 2

Fraction
no.

V
in mL

PH

water solubility
in µg/L

49

18.5

5.7

 < 44

50

18.5

5.7

 < 44

51

18.5

5.7

 < 44

52

18.5

5.7

 < 44

53

18.5

5.7

 < 44

 The water solubility was found to be below the quantification limit of 44 μg/L.

 

Coating check: The coating check was successful. Enough residual test item remained an the columns.

Conclusions:
The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L. 
Executive summary:

The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis . Therefore, two identical columns were prepared; one of them was exposed to a flow rate of about 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). The concentration of test item was determined by means of HPLC. The volumes of all fractions were measured. For the analysed fractions the pH values and the temperatures were measured, too. For column 1 the fractions 21 to 25 were evaluated. The water solubility was found to be smaller than 0.044 mg/L For column 2 the fractions 49 to 53 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L. 

Description of key information

The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L. 

Key value for chemical safety assessment

Additional information

The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis . Therefore, two identical columns were prepared; one of them was exposed to a flow rate of about 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). The concentration of test item was determined by means of HPLC. The volumes of all fractions were measured. For the analysed fractions the pH values and the temperatures were measured, too. For column 1 the fractions 21 to 25 were evaluated. The water solubility was found to be smaller than 0.044 mg/L For column 2 the fractions 49 to 53 were evaluated. The water solubility was found to be smaller than 0.044 mg/L. The water solubility at a temperature of 20 °C was determined to be below the quantification limit: < 0.044 mg/L.