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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Final report on the safety assessment of coconut oil, coconut acid, hydrogenated coconut acid, and hydrogenated coconut oil
Author:
Cosmetic Ingredient Review (CIR) Panel
Year:
1986
Bibliographic source:
Int. J. Toxicol. 5(3):103-121

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single dose of fully hydrogenated coconut oil was applied dermally to guinea pigs and animals were observed for 7 d.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Glycerides, C8-18 and C18-unsatd.
IUPAC Name:
Glycerides, C8-18 and C18-unsatd.
Constituent 2
Reference substance name:
Glycerides, C8-18 and C18-unsatd.
EC Number:
266-946-3
EC Name:
Glycerides, C8-18 and C18-unsatd.
IUPAC Name:
266-946-3
Constituent 3
Reference substance name:
67701-28-4
Cas Number:
67701-28-4
IUPAC Name:
67701-28-4
Details on test material:
- Name of test material (as cited in study report): Fully hydrogenated coconut oil (CAS N° 84836-98-6, EC N° 284-283-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18, C18-unsatd.’

Test animals

Species:
guinea pig

Administration / exposure

Type of coverage:
not specified
Duration of exposure:
Single dermal application
Doses:
3,000 mg/kg
No. of animals per sex per dose:
12
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
3 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality during 7 d observation period

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under test conditions, the acute dermal LD0 of the substance in guinea pigs was found to be greater than 3,000 mg/kg.
Executive summary:

A study was conducted to determine the acute dermal toxicity of the constituent glycerides, C8 -18 and C18 -unsatd. (in the form of fully hydrogenated coconut oil) in guinea pigs. The substance was applied at a dose of 3,000 mg/kg to the skin of 12 guinea pigs. No mortality occurred during the 7 d observation period. Under test conditions, the LD0 of the substance in guinea pigs was found to be 3,000 mg/kg (CIR, 1986).

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