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EC number: 905-287-4
CAS number: 1638758-52-7
toxicity: no deaths, no abortions or early deliveries
reduced food consumption, reduced maternal body weights and weight
gain during dosing period; reduced gestational weight gain (day 0-21);
signs of toxicity: hypoactivity, ataxia, tremors, audible respiration,
perioral wetness; increased relative but not absolute liver weights no
embryotoxicity or teratogenicity
was observed at any dosage level
Developmental toxicity study according to
TSCA Health Effects Test guidelines for Specific Organ/Tissue Toxicity -
Developmental Toxicity (EPA, 1984,1987):
Administration of m-cresol by gavage to
time-pregnant-Sprague Dawley rats during organogenesis at 0.0, 30, 175,
450 mg/kg bw/d resulted in maternal toxicity at 450 mg/kg bw/day
including significant reduction in periodic maternal body weights and
weight gain during the dosing period in addition with clinical signs of
toxicity (NOAEL (maternal toxicity) 175 mg/kg bw/d). m-Cresol did not
induce fetotoxicity or malformations at any dose level tested. (NOAEL
(developmental toxicity) >450 mg/kg bw).
The above results are suitable to be used for read across for Reaction
mass of 2,4-xylenol and 2,5-xylenol, due to the category being based on
structural similarity and comparable physicochemical properties, leading
to similar (eco)toxicological properties.
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