Registration Dossier
Registration Dossier
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EC number: 279-075-9 | CAS number: 79135-28-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 10th to 13thh, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- Pow
- Partition coefficient:
- 0.002
- Temp.:
- 20 °C
- pH:
- 4.4
- Type:
- log Pow
- Partition coefficient:
- -2.76
- Temp.:
- 20 °C
- pH:
- 4.4
- Conclusions:
- logPow is -2.76 at 20 °C and pH 4.4.
- Executive summary:
The partition coefficient (Pow) of Acid Brown 303 in n-octanol - water was determined to be 0.0017 ± 0.0004 (95 % confidence interval) at 20 °C and pH ~4.4, which corresponds to log Pow of -2.76 using the shake flask method, according to OECD guideline 107.
Reference
| ratio n-octanol:water | mean meas. conc. in n-octanol phase (µg/ml) | mean meas. conc. in aqueous phase (µg/ml) | pH |
| 5:1 | 0.02 | 14.7 | 4.44 |
| RSD % | 3 | 2 | - |
| measured quantity of test item | 0.8 µg | 113.2 µg | - |
| total nominal quantity | 106 µg | ||
| total measured quantity | 114 µg | ||
| recovery | 107% | ||
| 5:2 | 0.02 | 7.6 | 4.44 |
| RSD % | - | - | - |
| measured quantity of test item | 0.6 µg | 99.7 µg | - |
| total nominal quantity | 106 µg | ||
| total measured quantity | 100 µg | ||
| recovery | 95% | ||
| 10:1 | 0.04 | 28.9 | 4.42 |
| RSD % | 7 | 2 | - |
| measured quantity of test item | 1.8 µg | 121.4 µg | - |
| total nominal quantity | 106 µg | ||
| total measured quantity | 123 µg | ||
| recovery | 116% | ||
Calculated logPow
| ratio n-octanol:water | logPow | mean | pH |
| 5:1 | -2.83 | -2.84 | 4.44 |
| -2.87 | |||
| -2.84 | |||
| 5:2 | -2.57 | -2.6 | 4.44 |
| * | |||
| -2.63 | |||
| 10:1 | -2.79 | -2.84 | 4.42 |
| -2.86 | |||
| -2.85 | |||
| mean all with 95 % confidence interval | - | -2.76 | - |
Description of key information
logPow = -2.76 at 20 °C and pH 4.4
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.76
- at the temperature of:
- 20 °C
Additional information
OECD guideline 107.
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