Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
not specified
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction products of 2,3-epoxypropyl phenyl ether and 2,2'-iminodi(ethylamine)
EC Number:
948-518-4
Molecular formula:
(C13H23N3O2 . C31H43N3O6)x
IUPAC Name:
Reaction products of 2,3-epoxypropyl phenyl ether and 2,2'-iminodi(ethylamine)
Test material form:
liquid
Details on test material:
PGE-DETA adduct

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
ca. 0.3 - ca. 3.01
Temp.:
20 °C
pH:
ca. 3
Type:
Pow
Partition coefficient:
ca. 2 - ca. 1 020
Temp.:
20 °C
pH:
ca. 3
Details on results:
Overall log10 Pow: over the range <0.3 to 3.01
Overall Partition coefficient: over the range <2.0 to 1.02 x 103

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test item has been determined to be over the range <2.0 to 1.02 x 103, and a log10 Pow over the range <0.3 to 3.01.
Executive summary:

Partition Coefficient. Over the range <2.0 to 1.02 x 103, log10 Pow over the range <0.3 to 3.01, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.