Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
Ames-Test
Author:
Romualdo Benigni
Year:
2011
Bibliographic source:
CCRIS database,Toxnet databases, Bacterial mutagenicity ISSSTY

Materials and methods

GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Method

Species / strain
Species / strain / cell type:
other: TA 100 and TA 1535
Metabolic activation:
with and without
Metabolic activation system:
S9

Results and discussion

Test results
Species / strain:
other:
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion