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EC number: 429-780-4 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 MAY 2009 - 30 JUL 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- Shake-flask method used for preliminary estimation
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 25 °C
- pH:
- 6.6
- Details on results:
- According to this preliminary test the solubility of the test item in n-octanol is > 1048 g/L.
Dead time: t0 = 2.71 min.
Calibration data:
Regression: log Pow = a + b log k
Parameter: a = 4.08, b = 3.76, r^2 = 0.9190
log Pow of the test substance
1st injection: tR = 38.0 min
2nd injection: tR = 38.4 min
mean: tR = 38.2 min
k = 13.1
log k > 0.37 (above log Pow value of the highest calibration substance (DDT)) - (1.12 - via extrapolation)
log Pow = > 6.5 (above log Pow value of the highest calibration substance (DDT)) - (8.3 - via extrapolation) - Conclusions:
- The log Pow of the test was found to be > 6.5.
- Executive summary:
The log POW of the sample was tested according to EU Method A.8 and OECD Guideline 117 in a non-GLP study at 25 °C and at a pH of 6.6. The log POW is > 6.5, which is the value of the highest calibration substance. Via extrapolation a value of 8.3 was received as log POW.
Reference
Description of key information
The log POW of the sample was tested according to EU Method A.8 and OECD Guideline 117 in a non-GLP study at 25 °C and at a pH of 6.6. The log POW is > 6.5, which is the value of the highest calibration substance. Via extrapolationa a value of 8.3 was received as log POW.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 8.3
- at the temperature of:
- 25 °C
Additional information
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