Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
Classification based on calculation rules for mixtures of the CLP Regulation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference
Reference Type:
other: Guidance
Title:
Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
Author:
ECHA
Year:
2017
Bibliographic source:
ECHA-17-G-21-EN

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Classification based on calculation rules for mixtures of the CLP Regulation

Test material

Constituent 1
Reference substance name:
(1R,4R,5S)-4-methyl-1-(propan-2-yl)bicyclo[3.1.0]hexan-3-one; 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one; 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexan-3-yl acetate; 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexane
IUPAC Name:
(1R,4R,5S)-4-methyl-1-(propan-2-yl)bicyclo[3.1.0]hexan-3-one; 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one; 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexan-3-yl acetate; 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexane
Test material form:
liquid

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
other: classification
Remarks on result:
other: skin irritant category 2

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The substance is to be classified as Skin irritant Category 2
Executive summary:

The NCS is composed of several identified constituents and in that, it can be considered as a mixture according to the definition of the CLP Regulation.

The decision logic for classification of mixtures from the ECHA Guidance on the Application of the CLP Criteria (2017) was used to determine the skin irritation/corrosion hazard of the registered substance. The decision of classification as skin irritant was based on existing data on constituents (additivity principles):the registered substance has constituents classified as Skin Irritant Category 2 present at more than 10% and more than 10% of its constituents classified as Skin irritant Category 2 and should be classified as a skin irritant without further testingaccording to the rules for classification of mixtures of Regulation (EC) No 1272/2008

Constituent

 

CAS

Classification

Source

beta-thujone

471 -15 -8

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

alpha-pinene

80 -56 -8

H315

 ECHA C&L inventoryself classification & REACH disseminated dossier

 beta-pinene  127 -91 -3

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

 limonene  138 -86 -3

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

 para-cymene  99 -87 -6

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

 beta-myrcene  123 -35 -3

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

 terpineol-4  562 -74 -3

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

 
 alpha-terpineol  98 -55 -5

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

 
 delta-3 carene  13466 -78 -9  

H315

ECHA C&L inventoryself classification

 linalol  78 -70 -6

H315

ECHA C&L inventoryself classification & REACH disseminated dossier

Source: ECHA disseminated dossiersor self classification