bis(2,2,6,6-tetramethyl-1-(phenylthio)piperidin-4-yl)carbonate

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019-04-12 to 2019-05-27

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

adopted July 27, 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

31 May 2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Version / remarks:

August 1996

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

OGYÉI- National Institute of Pharmacy and Nutrition (22.05.2019)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

The test item was used in its initial form.

Atm. press.:

994.9 hPa

Decomposition:

yes

Decomp. temp.:

>= 303.8 - <= 330.96 °C

Appearance of the Samples

Before the test the appearance of the sample was white, crystallic powder. After the experiments the test item became a black melt in the crucible.

Measurement

The evaluation of the data was performed using the software STARe. As result, a thermogram was obtained in which the heat flow of the investigated sample is given as a function of the temperature. By integrating the area under the heat flow signals, the enthalpy of the process was obtained.

During the heating endotherm peak was observed in the temperature range of approx. 270 ˗ 337 °C which can be associated with the boiling of the test item. Based on the thermograms and the appearance of test item after the experiments it is concluded, that the test item decomposes during boiling.

Table: Summary of the DCS Test of test item

	Sample 1	Sample 2	Mean
Onset of effect [°C]	302.86	304.74	303.80
Endset of effect [°C]	330.94	330.97	330.96
Energy [J/g]	-241.68	-242.83	-242.26

Conclusions:

Based on the thermograms and the appearance of test item after the experiments it is concluded, that the test item decomposes during boiling.

Executive summary:

For the determination of the boiling point differential scanning calorimetry method was used. The test was carried out at normal atmospheric pressure.

Using a linear heating rate of 10 °C/min the boiling point of the test item was determined to be in the range of 303.8 – 331.0 °C (577.0 – 604.1 K) at atmospheric pressure (99.49 kPa), following internationally accepted guidelines (OECD 103, EU Method A.2, OPPTS 830.7220) and under GLP compliance. Based on the thermograms and the appearance of test item after the experiments it is concluded, that the test item decomposes during boiling.

Description of key information

For the determination of the boiling point differential scanning calorimetry method was used. The test was carried out at normal atmospheric pressure.

Using a linear heating rate of 10 °C/min the boiling point of the test item was determined to be in the range of 303.8 – 331.0 °C (577.0 – 604.1 K) at atmospheric pressure (99.49 kPa), following internationally accepted guidelines (OECD 103, EU Method A.2, OPPTS 830.7220) and under GLP compliance. Based on the thermograms and the appearance of test item after the experiments it is concluded, that the test item decomposes during boiling.