Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Additional information
Experimental data on the terrestrial aquatic toxicity of Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate are not available.The assessment was therefore based on data available for the conjugate acid Reaction mass of 2-(3,4-dimethyl-1H-pyrazol-1-yl)succinic acid and 2-(4,5-dimethyl-1H-pyrazol-1-yl)succinic acid (CAS 2241455-89-8). The read across approach is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Please refer to the analogue justification attached to IUCLID section 13 for a detailed justification.
Studies on the terrestrial toxicity of the source substance are
available for the earthworm Eisenia fetida and for the arthropod species
Folsomia candida. Supporting data is available for Apis mellifera.
Furthermore data investigating the effects of the source substance on
the carbon transformation by soil microorganisms is available.
In the long-term study with Eisenia fetida, an effect on reproduction
was observed at the highest test concentration 1000 mg/kg soil dw. The
NOEC was determined to be 500 mg/kg soil dw. The toxicity to Folsomia
candida was also tested in a long-term study with substance
concentrations up to 1000 mg test substance/kg soil. Effects of the
substance on F. candida were not observed. In the study with Apis
mellifera no effects were observed after oral or contact exposure at the
tested doses (118.4 μg a.i./bee and 100 µg a.i./bee, respectively). The
carbon transformation of soil microorganisms was not inhibited by the
substance up to a concentration of 37.65 mg/kg soil dw (EC10 (28 d) >
37.65 mg/kg soil dw).
Based on the available read-across data the toxicity of Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate to terrestrial organisms is expected to be low.
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