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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 10 October 2017 to 07 December 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Version / remarks:
2006
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
slow-stirring method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: CY71353002
- Expiration date of the lot/batch: 01/06/2019
- Purity test date: 01/06/2017
- Purity of the test item: 99.8%
Analytical method:
gas chromatography
Type:
log Pow
Partition coefficient:
> 1.5 - < 1.529
Temp.:
25 °C
pH:
> 7.14 - < 7.34
Remarks on result:
other: after 24 hours of stirring
Type:
log Pow
Partition coefficient:
> 1.489 - < 1.525
Temp.:
25 °C
pH:
> 7.14 - < 7.34
Remarks on result:
other: after 29 hours of stirring
Type:
log Pow
Partition coefficient:
> 1.542 - < 1.554
Temp.:
25 °C
pH:
> 7.14 - < 7.34
Remarks on result:
other: after 46 hours of stirring
Type:
log Pow
Partition coefficient:
> 1.57 - < 1.583
Temp.:
25 °C
pH:
> 7.14 - < 7.34
Remarks on result:
other: after 53 hours of stirring
Type:
log Pow
Partition coefficient:
> 1.534 - < 1.588
Temp.:
25 °C
pH:
> 7.14 - < 7.34
Remarks on result:
other: after 70 hours of stirring
Details on results:
In water phase:
Stirring time (hours) Test item (mg/l) Mean ratio Diethyl succinate (%) Mean ratio Diethyl glutarate (%) Mean ratio Diethyl adipate (%)
24 7.32 27.990 68.308 3.702
29 7.33 29.909 67.240 2.851
46 6.87 30.319 67.233 2.448
53 6.42 29.509 68.345 2.146
70 6.55 29.272 68.475 2.253

In n-octanol phase:
Stirring time (hours) Test item (mg/l) Mean ratio Diethyl succinate (%) Mean ratio Diethyl glutarate (%) Mean ratio Diethyl adipate (%)
24 11.84 19.775 67.084 13.141
29 11.78 19.775 67.207 13.017
46 12.07 19.603 67.122 13.276
53 12.18 19.841 66.971 13.187
70 12.04 19.690 67.078 13.232
Conclusions:
The log Kow of the test item was determined at 25°C with the slow stirring method. The value obtained is 1.54.
Executive summary:

The partition coefficient of the test item was determined according to the slow stirring method and recognised guidelines (OECD 123 and GLP). No deviation from the guidelines was observed during the test.

The mean log Kow value obtained at 25°C is 1.54. Therefore, the test item is not considered to possess a potential for bioaccumulation as the log Kow is lower than 4.

Description of key information

The partition coefficient of the test item was determined in a key study of Klimisch validity one, performed according to recognised guideline and under GLP.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.54
at the temperature of:
25 °C

Additional information

Based on its log partition coefficient (lower than 4), the test item is not considered to possess a potential for bioaccumulation.