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EC number: 264-709-9 | CAS number: 64157-14-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- no detailed information; observation period not sufficient to evaluate reversibility
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 12 May 1981
- Deviations:
- yes
- Remarks:
- no experimental details available, limited information on test material, limited data on test animals, housing or environmental conditions, observation period not sufficient to evaluate reversibility
- Qualifier:
- according to guideline
- Guideline:
- other: US-FHSA CFR Title 16. Chap. 11, Parts 1500.3, 1500.4, 1500.41, 1500.42
- GLP compliance:
- no
Test material
- Reference substance name:
- Hydrogen tetrakis[2,2-bis[(allyloxy)methyl]butan-1-olato-O1]bis(ditridecyl phosphito -O'')titanate(2-)
- EC Number:
- 264-709-9
- EC Name:
- Hydrogen tetrakis[2,2-bis[(allyloxy)methyl]butan-1-olato-O1]bis(ditridecyl phosphito -O'')titanate(2-)
- Cas Number:
- 64157-14-8
- Molecular formula:
- not applicable (UVCB substance)
- IUPAC Name:
- dihydrogen 2-{[(di{[bis(tridecyloxy)phosphanyl]oxido}tris({2,2-bis[(prop-2-en-1-yloxy)methyl]butyl}oxido)titaniotetrakis(ylium))oxido]methyl}-1-(prop-2-en-1-yloxy)-2-[(prop-2-en-1-yloxy)methyl]butane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- adult albino rabbits
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 3 days
Reading time points: 4, 24, 48 and 72 h - Number of animals:
- 6
- Details on study design:
- TEST SITE
- Type of wrap if used: The test substance was applied under a gauze dressing to the clipped intact skin of the animals.
OBSERVATION TIME POINTS : 4, 24, 48 and 72 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2, #4, #5
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritation parameter:
- edema score
- Basis:
- animal: #3, #5
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within the 72 h of observation
- Irritant / corrosive response data:
- While very slight erythrema (score 1) was observed after 4 h of exposure (4/6 animals), the erythema formation increased and was well-defined (score 2) or moderate to severe (score 3) at the reading time points 48 and 72 h (5/6 animals). Very slight edema (score 1) was observed 24 h following exposure (3/6 animals), increasing to slight to moderate edema (score 2) at 48 and 72 h (5/6 animals).
Any other information on results incl. tables
Table 1: Scores on erythema, eschar and edema formation
Erythema and eschar formation | Edema formation | |||||||||||
Animal No. | 1 | 2 | 3 | 4 | 5 | 6 | 1 | 2 | 3 | 4 | 5 | 6 |
4 h | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
24 h | 2 | 2 | 2 | 2 | 2 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
48 h | 2 | 2 | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 1 | 1 |
72 h | 2 | 2 | 3 | 2 | 2 | 1 | 2 | 2 | 2 | 2 | 2 | 1 |
Score 24/48/72 h | 2.0 | 2.0 | 2.7 | 2.0 | 2.0 | 1.0 | 1.0 | 1.0 | 1.3 | 1.7 | 1.3 | 0.7 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Skin Irrit. 2 (H315) according to Regulation (EC) No. 1272/2008
- Conclusions:
- CLP: skin irritant Cat. 2
The observation period was limited to 72 h. Erythema and edema persisted and no reversibility was observed untl 72 h. Since erythema and edema formation enhanced throughout the whole study observation perdiod and no reversibility can be assumed, the test item is classified as skin irritant Category 2 according to Regulation (EC) No. 1272/2008 in a worst-case approach.
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