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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
no detailed information

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
adopted 12 May 1981
Deviations:
yes
Remarks:
no detailed information
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydrogen tetrakis[2,2-bis[(allyloxy)methyl]butan-1-olato-O1]bis(ditridecyl phosphito -O'')titanate(2-)
EC Number:
264-709-9
EC Name:
Hydrogen tetrakis[2,2-bis[(allyloxy)methyl]butan-1-olato-O1]bis(ditridecyl phosphito -O'')titanate(2-)
Cas Number:
64157-14-8
Molecular formula:
not applicable (UVCB substance)
IUPAC Name:
dihydrogen 2-{[(di{[bis(tridecyloxy)phosphanyl]oxido}tris({2,2-bis[(prop-2-en-1-yloxy)methyl]butyl}oxido)titaniotetrakis(ylium))oxido]methyl}-1-(prop-2-en-1-yloxy)-2-[(prop-2-en-1-yloxy)methyl]butane

Test animals

Species:
rat
Strain:
Sprague-Dawley
Remarks:
Albino
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 – 300 g
- Fasting period before study: 18 h
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
1000, 2000, 4000, 8000 and 16000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
Statistics:
The LD50 was determined by Litchfield Wilcoxin Method

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 600 mg/kg bw
Based on:
test mat.
95% CL:
3 200 - 6 600
Mortality:
1000 mg/kg bw: 0/5 males and 0/5 females died
2000 mg/kg bw: 0/5 males and 0/5 females died
4000 mg/kg bw: 0/5 males and 0/5 females died
8000 mg/kg bw: 2/5 males and 2/5 females died
16000 mg/kg bw: 5/5 males and 5/5 females died
Gross pathology:
Autopsy was unremarkable, major organs all appeared normal. Slight distention of stomach was noted. No signs of gross toxiciuty were observed.

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
Conclusions:
CLP: not classified