Registration Dossier
Registration Dossier
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EC number: 283-882-1 | CAS number: 84775-52-0 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Curcuma longa, Zingiberaceae.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Remarks:
- Sample sent to sa-FORD, Plot V -10, MIDC Industrial Area, Taloja, Dist Raigad, Navi Mumbai, PIN: 410208, Maharashtra, India
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 74 days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Curcuma longa, ext.
- EC Number:
- 283-882-1
- EC Name:
- Curcuma longa, ext.
- Cas Number:
- 84775-52-0
- Molecular formula:
- C15H22O
- IUPAC Name:
- (6S)-2-methyl-6-(4-methylphenyl)hept-2-en-4-one and 2-Methyl-6-(4-methylcyclohexa-2,4-dien-1-yl)hept-2-en-4-one and 2-methyl-6-(4-methylidene-1-cyclohex-2-enyl)hept-2-en-4-one
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- corn oil
- Doses:
- 300 and 2000mg/ kg
- No. of animals per sex per dose:
- 3 animals per dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No abnormalities showed during external and internal gross pathological examination o terminally sacrified animals
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Acute Oral Toxicity study for Turmeric Oil was performed on Wistar Rat (female) and is classified as 'Category 5 or unclassified' in Compliance with the OECD guidelines No. 423.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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