Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
oxidising solids
Study period:
15 May 2019
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
UN Manual of Tests and Criteria: Test O.1 (Test for oxidizing solids)
Version / remarks:
Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria, 6th edition, New York and Geneva, 2015
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Reference substance 001
Cas Number:
67-47-0
Molecular formula:
C6H6O3
impurity 1
Chemical structure
Reference substance name:
Fructose
EC Number:
200-333-3
EC Name:
Fructose
Cas Number:
57-48-7
Molecular formula:
C6H12O6
IUPAC Name:
D-fructose
impurity 2
Chemical structure
Reference substance name:
1-(furan-2-yl)-2-hydroxyethanone
Cas Number:
17678-19-2
Molecular formula:
C6H6O3
IUPAC Name:
1-(furan-2-yl)-2-hydroxyethanone
impurity 3
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
water
impurity 4
Chemical structure
Reference substance name:
Sodium formate
EC Number:
205-488-0
EC Name:
Sodium formate
Cas Number:
141-53-7
Molecular formula:
CH2O2.Na
IUPAC Name:
sodium formate
impurity 5
Chemical structure
Reference substance name:
Sodium nitrate
EC Number:
231-554-3
EC Name:
Sodium nitrate
Cas Number:
7631-99-4
Molecular formula:
HNO3.Na
IUPAC Name:
sodium nitrate
impurity 6
Chemical structure
Reference substance name:
Glucose
EC Number:
200-075-1
EC Name:
Glucose
Cas Number:
50-99-7
Molecular formula:
C6H12O6
IUPAC Name:
D-glucose
impurity 7
Chemical structure
Reference substance name:
Sodium acetate
EC Number:
204-823-8
EC Name:
Sodium acetate
Cas Number:
127-09-3
Molecular formula:
C2H4O2.Na
IUPAC Name:
sodium acetate
impurity 8
Chemical structure
Reference substance name:
2-furaldehyde
EC Number:
202-627-7
EC Name:
2-furaldehyde
Cas Number:
98-01-1
Molecular formula:
C5H4O2
IUPAC Name:
2-furaldehyde
impurity 9
Chemical structure
Reference substance name:
Sodium 4-oxovalerate
EC Number:
243-378-4
EC Name:
Sodium 4-oxovalerate
Cas Number:
19856-23-6
Molecular formula:
C5H8O3.Na
IUPAC Name:
sodium 4-oxopentanoate
impurity 10
Chemical structure
Reference substance name:
Formaldehyde
EC Number:
200-001-8
EC Name:
Formaldehyde
Cas Number:
50-00-0
Molecular formula:
CH2O
IUPAC Name:
formaldehyde
Test material form:
solid: crystalline
Details on test material:
freeze-dried material
Batch: 1808A-RO-C-I1-FD-Chg#3
Appearance Crystal / brown
Storage: Refrigerator (2 - 8 °C)
Expiring date: 31 December 2019
Specific details on test material used for the study:
Storage Conditions: Dry, dark and cooled (2 °C to 8 °C)
Expiry Date: 2019-12-31

Results and discussion

Test results (Oxidising solids)
Key result
Remarks on result:
other: Based on the chemical composition of the product and the chemical structure of the single components present in the test item, it is concluded that the test item has no oxidizing properties.

Any other information on results incl. tables

The main components 5-(Hydroxymethyl)furfural (CAS no. 67-47-0), Fructose (CAS no.  57-48-7), 1-(furan-2-yl)-2-hydroxyethan-1-one (CAS no. 17678-19-2), Glucose (CAS no.  50-99-7) and Sodium formate (CAS no. 141-53-7) contain oxygen chemically only bonded to carbon or hydrogen. For these components oxidizing properties can be excluded. 

The test item also contains a small amount Sodium nitrate (CAS no. 7631 -99 -4), which is classified as oxidizing solid in Division 5.1 (Packing Group III) according to UN Recommendations on the TRANSPORT OF DANGEROUS GOODS: Model Regulations Volume I, Rev. 20, New York and Geneva, 2017. Since all other main components do not have oxidizing properties, it can be stated that the small amount of Sodium nitrate will not have an effect on the oxidizing potential of the whole product. The same applies to the other components with a mass fraction below 1 % w/w.

In addition, the test item contains no other components except for water, which is known to have no oxidizing properties.

Based on the fulfillment of the above cited requirements of Appendix 6 for the main components, it can be stated that the test item 5-(Hydroxymethyl)furfural has no oxidizing properties.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the chemical composition of the product and the chemical structure of the single components present in the test item, it is concluded that 5-(Hydroxymethyl)furfural has no oxidizing properties.
Based on the chemical structures, the test item should not be classified by:
UN Transport Regulation: The test item does not have to be classified as oxidizing solid in Division 5.1 according to the UN Transport Regulation.
GHS and EC 1272/2008 (CLP Regulation), Annex 1: 2.14: The test item does not have to be classified as oxidizing solid according to GHS and EC 1272/2008 (CLP Regulation) Annex 1: 2.14.
Executive summary:

Based on the chemical composition of the product and the chemical structure of the single components present in the test item, it is concluded that 5-(Hydroxymethyl)furfural has no oxidizing properties.  

Based on the chemical structures, the test item should not be classified by:

UN Transport Regulation: The test item does not have to be classified as oxidizing solid in Division 5.1 according to the UN Transport Regulation.

GHS and EC 1272/2008 (CLP Regulation), Annex 1: 2.14: The test item does not have to be classified as oxidizing solid according to GHS and EC 1272/2008 (CLP Regulation) Annex 1: 2.14.