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Physical & Chemical properties

Surface tension

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Administrative data

Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides
Author:
Sot et al.
Year:
2005
Bibliographic source:
Biochimica et Biophysica Acta 1711 (2005) 12–19. doi:10.1016/j.bbamem.2005.02.014

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Langmuir balance and fluorescence techniques
GLP compliance:
not specified
Type of method:
other: Determination of equilibrium values in surface pressure at an air–water interface

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Specific details on test material used for the study:
Ceramides were supplied by Avanti Polar Lipids (Alabaster, AL). All lipids were > 98 % pure as supplied and were used without further purification. All other reagents were of analytical grade.

Results and discussion

Surface tension
Key result
Remarks on result:
not determinable
Remarks:
A ceramide with C16 was not modifying the surface pressure of the aqueous solutions into which it was included.

Applicant's summary and conclusion

Conclusions:
Long-N-acyl chain ceramides (C≥16) do not cause a change in surface pressure.
Executive summary:

According to the study by Sot et al. (2005), long-N-acyl chain ceramides (C≥16) are highly hydrophobic and essentially insoluble and non-dispersible in water. Their studies show that long-chain ceramides belong in the category of insoluble non-swelling amphiphiles, implying that they cannot give rise to micelles or other hydrated aggregates in water suspension.