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EC number: 274-354-1 | CAS number: 70161-18-1
The purpose of this test was to identify test items that can induce serious eye damage and to identify test items not requiring classification for eye irritation or serious eye damage. The Bovine Corneal Opacity and Permeability (BCOP) test method is an organotypic model that provides short-term maintenance of normal physiological and biochemical function of the bovine cornea in vitro. In this test method, damage by the test item is assessed by quantitative measurements of changes in corneal opacity and permeability.
The study was performed in compliance with: OECD Guideline for the Testing of Chemicals No. 437 (updated 09 October 2017) “Bovine Corneal Opacity and Permeability Assay” and Method B.47 of Commission Regulation (EC) No. 440/2008, in accordance with GLP.
The corneas treated with the test item appeared clear with no staining, however some test item remained adhered to the sides of all chambers causing the clear MEM to turn pale orange post treatment. The corneas treated with the negative control item were clear post treatment. The corneas treated with the positive control item were cloudy post treatment.
No prediction of eye irritation can be made.
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